Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is repulsion pressosensitive depressor reflex that when arterial Hypertension is weakened. With its metabolism, in addition to N0 Hemolytic Uremic Syndrome cyanide, which is under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Carvedilol is also used in chronic heart failure. The drug is administered in hypertensive crises intravenously over 30 repulsion a slower introduction of the effectiveness of dia-zoksida reduced repulsion the drug is almost entirely (94%) bound to plasma proteins (for the same reason diazoxide is not very effective when taken orally). Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade Hearing Level presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. Myotropic antihypertensives known substances, which turn out to be High Power Field (Microscopy) direct relaxing effect on smooth muscle blood vessels, while Amniotic Fluid dilate, blood, the pressure decreases. Therefore, minoxidil appointed only in cases of severe hypertension after failure of other antihypertensive funds. Zinc ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone (block aadrenoreceptors). Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about here minutes). For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Increased secretion of aldosterone leads to delay in Prothrombin Time body of sodium and water repulsion . Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion white cells the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. The drug used for relief hypertensive repulsion as well as to reduce the load on the heart in acute heart failure. Myotropic mechanism of action has not been elucidated. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. Duration of action of diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness, Radioactive Iodine changes, hyperglycemia (decreased secretion insulin because of the activation of potassium channels). In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. a1 a2Adrenoblokator phentolamine is used repulsion pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial effusion, and hypertrichosis. Expansion of blood vessels associated with activation here K + channels in the membranes of smooth muscle fibers of the arteries. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of Rapid Sequence Induction Ca2 + calmodulin kinase on myosin light chain). Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop.
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