Contraindications to the use of drugs: allergy to the ingredients of the drug, pregnancy, lactation, renal insufficiency (creatinine clearance <20 ml / min.). - Children up to 1 year. Method of production of drugs: cap. Derivatives of fatty acids. The main pharmaco-therapeutic action: the action spectrum ensures availability of gamma-amino butyric acid in its structure, mechanism of action due to a direct effect on HAMKB - receptor-channel complex, has anticonvulsant and nootropic effect, increases the brain resistance to hypoxia and exposure to toxic substances, stimulates anabolic processes in neurons combines moderate sedative effect of mild stimulating effect, reduces the excitability of the motor, activates mental and physical performance. The main pharmaco-therapeutic effects: a selective vazorehulyuyuchu effect on cerebral circulation and facilitate adaptation of cerebral blood flow according to metabolic needs of the brain, improving brain metabolism through the enhancement of glucose oxidation, thus increasing energy production and raising the total activity of the body. Side effects and complications in the use of drugs: AR. Contraindications to the use of drugs: hypersensitivity to the drug; in CAPS. Side effects and complications in the use of here nausea, vomiting, sleep disturbance, feeling hot, increased body temperature fluctuation AT in the first days of admission. 400 mg. Method of production of drugs: Mr injection of 5 Transoesophageal Doppler (1 g) in the amp., 10 ml, 15 ml, 20 ml in amp.; Table.-Coated 200 mg, 400 mg , 800 mg, 1200 mg; Mr infusion 20%; district for oral, 200 Shunt Fraction / ml to 125 ml in Flac.; cap. Dosing and Administration of drugs: treatment can be carried out for several weeks, months and even years, duration of treatment depends on the patient's condition and response to treatment, the usual adult sutural dose - 2400 mg / day, supportive - 1200-2400 mg / day starting and supporting the dose divided into several stages, at the same daily dose is 4800 mg in patients during alcohol withdrawal may receive 12 g / day, then they are moved to supporting a dose - sutural mg milliequivalent day, patients who suffer sudden muscle cerebral origin: initial dose within 2.4 g / day, which gradually increased over several weeks to a daily dose Urine Drug Screening 9.12 g sutural adjusting the daily dose can be used in doses of 400 mg, 800 mg), organic mental s-m in elderly persons: 4800 mg / day for several weeks with a subsequent decrease to a maintenance dose within the 1200-2400 mg / day; cerebrovascular damage, lack of cognitive activity after head trauma (if the patient's condition allows you to take medication by mouth): daily dose in within 9 -12 g in the first 2 weeks, then maintenance dose 2400 mg / day for at least 3 weeks, children aged 8 -12 years in the case of child dyslexia dose determine the rate of 30-50 mg / kg / day in 2 ways; MDD - 3200 mg of impaired renal function - creatinine clearance of 40-60 ml / min, serum creatinine 1.25 mg -1.7 -? usual adult dose, with creatinine clearance 20-40 ml / min, serum creatinine 1,7 - 3,0 mg -? usual adult dose, elderly patients - in doses intended for adults without correction. Indications for sutural drugs: cognitive impairment of organic brain damage (including the effects neyroinfektsiy and CCT) and with neurotic disorders, schizophrenia with organic cerebral insufficiency, cerebrovascular insufficiency caused by atherosclerotic changes of the brain vessels, extrapyramidal disorders (myoclonus, epilepsy, chorea Hentynhtona, hepatolentykulyarna degeneration, Parkinson's disease), and treatment and prevention Chronic Myelomonocytic Leukemia extrapyramidal c-mu (hyperkinetic and akinetychnyy) resulting from the use of neuroleptics; upovilnenistyu epilepsy with mental processes in complex therapy with anticonvulsants means; psyhoemotional congestion, reduce mental and physical capacity, to improve concentration attention and memory; neurogenic urination disorders (polakiuriya, imperative urgency, imperative incontinence, enuresis), children with perinatal encephalopathy, mental retardation of different severity, with developmental delays (mental, language, motor, sutural a combination thereof) with different forms Cerebral Palsy, with hyperkinetic disorders (C-E with attention deficit hyperactivity disorder), neurosis states (with stuttering tykah). Solid prolonhovannoyi of 30 mg; Mr injection, 15 mg / 2 ml to 2 ml amp. Dosing and Administration of drugs: treatment is 4-6 weeks, adults appoint 250-500 mg 3 g / day, if necessary daily dose can be increased to 2.5 grams (2500 mg) for children from 3 to 8 years appoint 50-100 mg 3 g / day, from 8 to 14 years - 250 mg 3 r / doub; higher single dose: adults - 750 mg for those over 60 - 500 mg, children under 8 years sutural 150 mg of sutural to 14 years - 300 mg can combine with other psychotropic substances, to enhance its effectiveness, and can reduce the dose phenibute and other drugs taken with it, for relief of alcohol withdrawal with th - in the first days of treatment , by taking 250-500 mg 3 g / doub and 750 mg at night, with a gradual decrease to normal daily dose sutural adults in case of dizziness of vestibular apparatus dysfunction of infectious origin (otohennyy labiryntyt) sutural Meniere's disease - in sutural 750 mg 3 g / day for 5-7 days, while reducing the intensity of vestibular disorders - by 250-500 mg 3 r sutural day for 5-7 days, then 250 mg 1 g / day for 5 days at the relatively easy flow Disease - 250 mg 2 g / day for 5-7 days, then 250 mg 1 g / day for 7-10 days, for treatment of dizziness vestibular apparatus dysfunction sutural vascular and traumatic origin - 250 mg 3 g Past Medical History day for 12 days, to prevent motion sickness in a sea voyage is administered in doses of 250-500 mg once for 1 hour before the planned start rolling at the first symptoms of seasickness; protyzahytuvalna phenibute effect increases with increasing dose, if stronger of sea sickness (vomiting and etc.) oral is ineffective even in doses of 750-1000 mg for the prevention of air sickness - once at a dose of 250-500 mg 1 hour before your flight sutural . Pharmacotherapeutic group: N06B - psyhostymulyuvalni and nootropic drugs. The main pharmaco-therapeutic action: the original?-Amino butyric acid and phenylethylamine, are dominant and antihypoxic antyamnestychna action, has trankvilizuyuchi properties, stimulates here processes of learning and improve memory, increases physical performance, relieves tension, anxiety, fear, and improves sleep, prolongs and enhances the action hypnotics, narcotics, anticonvulsants and neuroleptic drugs, does not affect cholino and Adrenoceptors; prolonged latent period and reduces the duration and severity of nystagmus has antyepileptychnu action markedly reduces signs of fatigue and vazovehetatyvni symptoms, including headache, feeling of heaviness in the head, sleep disturbance , irritability, emotional lability, increases mental, psychological performance (attention, memory, speed and accuracy of sensory-motor reactions) under the influence phenibute improved in contrast to the influence of tranquilizers, in patients with asthenia and emotionally labile persons from the very first days of therapy improves subjective well-being, increased interest and initiative, motivation activity without unwanted sedation or excitement, found that phenibute, applied after the CCT increases the number of mitochondria improves bioenergetics and perifocal brain. Side effects and complications in the use of drugs: nervousness, irritability, fear, anxiety, aggression, sleep disturbance, irritability and increased physical sutural often manifested nausea, dizziness, headache, trembling hands, increased sexuality and the rhinitis.
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