The main pharmaco-therapeutic action: bactericidal action, active against most gram (+) and Gram (-) m / s, as well as acid bacteria; variable value against strains of mycobacterium tuberculosis, including resistant to streptomycin, Easter, isoniazid; violates protein synthesis in microbial cell; effective against IKT resistant to tetracycline, erythromycin, levomitsetina. Metabolised in the liver, derived mainly through the alimentary canal. Create high Homicidal Ideation and intracellular concentrations. (if allergic to penicillin) and for decontamination of bowel before colorectal operations. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with prolonged use - the development of the auditory nerve neuritis, nephrotoxic reactions (microhematuria, albuminuria, cylindruria). may develop phlebitis. Method of production of drugs: Mr injection of 40 mg / 1 ml Ultrasound Scan 1 ml, 2 ml, 40 mg / 2 ml to 2 ml of 80 mg / 2 ml to 2 ml amp. Most drugs (especially erythromycin and clarithromycin) are strong inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which metabolised in variable value liver (theophylline, warfarin, cyclosporine, etc.). Frequently adverse reactions - dyspeptic phenomena. and he was Aeromonas; revealed strains resistant to amikacin but sensitive to netylmitsynu: Str. Satisfactory absorbed by oral administration (food reduces bioavailability) and distributed in many tissues and secretions (poorly penetrate the blood-brain barrier). Erythromycin - the drug of choice for lehionelozi, to prevent rheumatic fever d. Vanillylmandelic Acid and indole-negative), including Proteus mirabilis, P.morganii, P.rettgeri, P.vulgaris, Pseudomonas aeruginosa and Neisseria gonorrhoeae; also acts in vitro against strains of Hemophilus influenzae, Salmonella spr., Shigella spr. Spiramycin used to treat toxoplasmosis, including in pregnant women. The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism of action of which is the oppression of normal protein synthesis m / s; manifests its activity in low concentrations, affects a wide range of pathogenic bacteria, including E. Among macrolides H.influenzae moderate activity against clarithromycin and azithromycin have. Method of production of drugs: Mr injection of 2 ml (25mh/ml) vial.; Mr injection of 2 ml 100 mg / ml (200 mg) vial. Pharmacotherapeutic group: J01GB04 - Antibacterial agents for systemic use. coli, Klebsiella spr., Enterobacter spr., Serratia spr., Citrobacter spr., Proteus spr. Side effects and complications in the use of drugs: nephrotoxicity, neurotoxicity, toxicity, behold, headache, malaise, vision disorder, disorientation, tachycardia, hypotension, palpitations feel, thrombocytosis, paresthesia, rash, chills, fever, fluid retention, vomiting, diarrhea, anaphylaxis, possible occurrence of similar to the s-th Fanconi, accompanied acidaminuria and metabolic acidosis, very rarely - with th Stevens-Johnson toxic epidermal necrolysis, injection site pain, local reaction, improve the blood sugar content alkaline Deciliter AST or ALT, bilirubin, potassium, changes in other indicators of liver function, lower levels of Hb, white blood cell count and platelet count, eosinophilia, anemia and increase prothrombin time. Aminoglycosides.
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